SHLV-5V Fully Automatic Vacuum Pre-filled Syringe Filling and Stoppering Machine

BRIEF INTRODUCTION

The SHLV-5v Automatic Vacuum Filling & Stoppering Machine is designed for the vacuum filling and stoppering process of prefilled syringes. The machine adopts independent vacuum systems for filling and stoppering operations, equipped with high-precision vacuum sensors to ensure a stable vacuum environment and clean process control. Key components are made of 316L stainless steel to fully comply with GMP requirements. Featuring full servo control and automatic robotic handling, the machine delivers high-precision positioning and stable operation. It supports multiple filling and stoppering methods with convenient format changeover, making it suitable for aseptic pharmaceutical production.
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Standalone Function

Independently performs the vacuum filling and vacuum stoppering processes, meeting GMP requirements for aseptic production of prefilled syringes.

 

Applicable Packaging & Specifications

  • Packaging Type: Nest-type Prefilled Syringes 

  • Applicable Syringe Size: 0.5 – 20 mL 

  • Filling Range: 0.2 – 20 mL 

  • Number of Filling Heads: 5 Heads 

  • Max. Output Capacity: 75 pcs/min 

  • Filling Method: Piston Pump or Peristaltic Pump 

  • Stoppering Method: Vacuum Stoppering or Mechanical Stoppering 

 

Process Flow

Loading → Machine Process: Robotic Picking → Vacuum Filling → Vacuum Stoppering → Discharge

 

Key Performance Parameters

Item

Specification

Remarks

Filling Accuracy

±1%

Based   on 1 mL filling volume

Robotic   Arm Control

Vertical   + Rotary Servo Control

Stable   pick-and-place operation

Positioning   Accuracy

X/Y   Servo Axis Positioning

High-precision   movement

Control   Mode

Full   Servo Control

Multi-axis   synchronization

Alarm   System

Multi-sensor   Alarm System

Overload   / Reverse / Liquid Level

 

Structure & GMP Design

  • The vacuum filling and vacuum stoppering systems adopt independent vacuum circuits for separate control. All pipelines are equipped with capsule filters and sanitary diaphragm valves to ensure high-level cleanliness control.

  • The vacuum chamber and all critical product-contact parts are made of 316L stainless steel, including filling needles, stoppering components, and piping systems. Selected key components are made of PEEK material to ensure corrosion resistance and sealing performance.

  • The machine is equipped with a vacuum air-return system and high-precision vacuum sensors for real-time vacuum monitoring and adjustment.

  • The stopper feeding system adopts a vibrating bowl and track conveying structure made of 316L stainless steel, with minimum level detection and buffer storage design to ensure stable stopper feeding.

  • The center plate adopts a 316L stainless steel clamping structure and is equipped with an automatic opening mechanism for convenient operation and maintenance.

  • The machine supports quick format changeover design to improve production flexibility and changeover efficiency.

 

Control System

  • The machine adopts a Siemens CPU control unit together with a servo control system to realize synchronized multi-axis servo control for the entire machine.

  • The robotic handling station is fully servo-driven, including vertical and rotary movements, ensuring accurate and stable pick-and-place operation.

  • High-precision X/Y servo moving axes are configured for accurate positioning.

  • The system is equipped with automatic monitoring functions for real-time monitoring of the vacuum circuit status and diaphragm valve switching actions.

  • Multiple sensor alarm functions are provided, including filling needle overload alarm, stopper reverse detection alarm, and material level detection alarm, improving operational safety and machine stability.

  • Vacuum air-return pressure and timing can be adjusted to meet different process requirements.


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